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  5. Life Science

Office & Commercial

Life Science

Life Science illustration

Life science real estate development in the United States is a rapidly growing segment, driven by burgeoning demand from biotech firms, pharmaceutical companies, and research institutions. As of 2023, the U.S. life science real estate market was valued at around $35 billion, with a compound annual growth rate of approximately 10%. This surge is fueled by increased investment in biomedical research, an aging population requiring more healthcare services, and the continuous evolution of biotechnology.

Key markets for life science real estate include Boston, San Francisco, and San Diego, known for their robust ecosystems of research universities, hospitals, and biotech startups. These areas offer a unique blend of talent, technology, and capital, making them attractive for both developers and tenants. Boston, for example, has over 30 million square feet of lab space, underscoring its position as a leading hub in this sector.

The design and construction of life science facilities are highly specialized, requiring advanced ventilation systems, clean rooms, and adaptable lab spaces. The capital expenditure per square foot for life science buildings is significantly higher than traditional office spaces, often exceeding 50-60%. This reflects the complex infrastructure and stringent regulatory requirements essential for research and development activities.

Investors and developers are increasingly recognizing the resilience and long-term potential of the life science real estate market. Institutional investors, such as pension funds and REITs, are actively expanding their portfolios in this sector. The robust demand for life science facilities, coupled with the limited supply of suitable spaces, has led to low vacancy rates, typically below 5% in top markets, and robust rent growth, further solidifying its attractiveness as an investment class. The convergence of scientific innovation and real estate development in this field is poised to continue shaping the landscape of the U.S. real estate market.

Developers building in Life Science

308 in the database
Lupoli Companies
Lupoli Companies
MA, United States
Lupoli Companies cover image
Employees501–1,000
Principals14
Markets1
Last updated: Oct 1, 2026
Harvest Properties
Harvest Properties
Oakland, CA
Harvest Properties cover image
Employees51–200
Principals23
Markets4
Last updated: Oct 1, 2026
Samet Corporation
Samet Corporation
NC 27409, USA
Samet Corporation cover image
Employees501–1,000
Principals9
Markets6
Last updated: Oct 1, 2026
JP DiNapoli Companies
JP DiNapoli Companies
California 95113, US
JP DiNapoli Companies cover image
Employees11–50
Principals2
Markets1
Last updated: Oct 1, 2026
Oldham Goodwin
Oldham Goodwin
TX 77802, USA
Oldham Goodwin cover image
Employees501–1,000
Principals10
Markets3
Last updated: Oct 1, 2026
Ionic Development Company
Ionic Development Company
225 Franklin St. 26th Floor Boston, MA
Ionic Development Company cover image
Employees2–10
Principals2
Markets1
Last updated: Oct 1, 2026
View all 308 developers in Life Science

Top markets for Life Science

  • California· 147
  • Massachusetts· 101
  • Texas· 90
  • New York· 77
  • North Carolina· 70
  • District of Columbia· 66
  • Florida· 66
  • Illinois· 59

Typical unlevered yield on cost

5.0 - 7.0%

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